Familial erythrophagocytic reticulosis. Complete response to combination chemotherapy.

Familial erythrophagocytic reticulosis. Complete response to combination chemotherapy.

Two infants with familial erythrophagocytic reticulosis attained a durable complete remission after combination chemotherapy including intrathecal methotrexate. Though both later died, neither child had definitive evidence of tumour at necropsy.

Familial histiocytic reticulosis (familial haemophagocytic reticulosis).

The clinical and pathological findings are recorded in two siblings who died in early infancy from familial histiocytic (;haemophagocytic') reticulosis. The nature of this condition is obscure but probably represents a primary histiocytosis. The only other family on record is that described by Farquhar and Claireaux (1952) and by Farquhar, Macgregor, and Richmond (1958).

Familial haemophagocytic reticulosis.

Immunotherapy in patients with less than complete response to chemotherapy.

BACKGROUND Patients with metastatic solid tumors (MST) with less than a complete response to chemotherapy (L-CR), a depressed immune system and elevated serum vascular endothelial growth factor (VEGF) lack defined treatment options. The primary endpoint evaluated in this study was whether interleukin-2 (IL-2) and 13-cisretinoic acid (RA) treatment reduced VEGF and improved immune function in su...

Idarubicin-bromelain combination sensitizes cancer cells to conventional chemotherapy

Objective(s): The primary cytotoxic effects of anticancer drugs like idarubicin, a chemotherapeutic agent, are not limited to neoplastic cells; they also produce similar effects in normal cells. In this study, we hypothesized that the combination of idarubicin-bromelain could make cancer cells more susceptible to cytotoxicity and genotoxicity.Material...